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SAMe, short for S-adenosylmethionine, is present in every living cell in the body. It plays an important role in many critical cellular functions, mood modification, and joint health, and can be used to lower elevated homocysteine levels.

SAMe levels tend to decline with age. People who feel blue, have mild to moderate depression, suffer from joint discomfort, crave carbohydrates, have high homocysteine levels, or have PMS may benefit by taking supplemental SAMe.

Available: 60 Capsules


  • Helps with depression
  • Premenstrual Syndrome (PMS)
  • Carbohydrate cravings
  • Joint mobility and support
  • Lowers homocysteine


Short for S-adenosylmethionine, SAMe is present in every living cell in the body and plays an important part in many critical cellular functions. Dozens of clinical studies have demonstrated that SAMe supports joint comfort and function and mobility in the spine, hips, and knees. It is important to the joints because of its critical role in cartilage formation.

Studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier, where it affects the synthesis and activation of various proteins, such as neurotransmitters.

SAMe also plays a role in transmethylation. Transmethylation reactions affect the synthesis, activation, and metabolism of various biological molecules.

SAMe can donate methyl groups to aid in the metabolism of homocysteine, lowering homocysteine levels in the body.

Because SAMe levels tend to decline with age, taking supplemental SAMe can be beneficial.

Suggested Use: Take 2 tablets, 1 to 3 times daily on an empty stomach or as prescribed by your health care provider.


SAMe is a stable, bioavailable form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed to prevent breakdown and inactivation of the ingredients.


Suggested Use: Take 2 tablets, 1 to 3 times daily on an empty stomach or as prescribed by your health care provider.

Does Not Contain: Contains no yeast, dairy, egg, gluten, soy, wheat, sugar, salt, preservatives, or artificial color, flavor or fragrance.

Caution: You should not take SAM-e if you have bipolar disease unless directly under the supervision of your psychiatrist. People who are already taking a prescription drug for depression or anxiety should check with their doctor or pharmacist before using SAMe. If you are pregnant, may become pregnant, are breastfeeding, or are taking antidepressant medication, consult your physician before using this product. In a small percentage of people this product may cause nausea or gastrointestinal upset. If you experience discomfort, discontinue use.

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